SIMPATHY project aims to provide you with targeted resources whatever your role in tackling polypharmacy and adherence. Targeted communication with key stakeholders is at the heart of SIMPATHY, to embrace the full range of channels and mechanisms underpinning necessary change to the vision and the ability to respond to all stakeholders. Both EU policymakers and healthcare providers need to be involved to effectively address polypharmacy and adherence in complex chronic patients. Polypharmacy is a major challenge in the case of patients with chronic conditions and complex needs. The expansion of the “care team” should include multiple actors: patient, caregivers, community services, NGOs, managers, decision makers in parallel also expands the type of health professionals and allied actors.